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Based on Published Research

Validity of Clinical Assessment in Suspected Pulmonary Embolism Prior to Having Computed Tomography Pulmonary Angiogram (CTPA)

M Haris, S Agarwal, B Kapur, T Fatima, MD Winson

American Thoracic Society International Conference, San Diego, California • Poster

Medicine Needs Mind, Not Just Machines

Medicine Needs Mind, Not Just Machines

Balancing clinical judgment with advanced imaging is vital. I explore the risks of over-testing and the art of diagnosis in modern practice.

✍️Dr. Sanjeev Agarwal
đź“…December 28, 2025
⏱️6 min read

Introduction

In the field of respiratory medicine, few diagnoses carry as much immediate weight as a Pulmonary Embolism (PE). It is a condition that demands respect; missed, it can be fatal, but diagnosed correctly, it is highly treatable. In recent years, the CT Pulmonary Angiogram (CTPA) has firmly established itself as the gold standard for diagnosis. It is a marvel of modern medical imaging—quick, precise, and definitive.

However, as we lean more heavily on technology, I have observed a concerning trend: the gradual erosion of clinical assessment in favor of immediate imaging.

Having conducted extensive research on the validity of clinical assessment in suspected PE, and drawing from my experience transitioning from the protocol-driven National Health Service (NHS) in the UK to private practice in India, I feel compelled to address this balance. We must ask ourselves: are we using our clinical skills to guide our investigations, or are we allowing investigations to replace our clinical skills?

The Clinical Dilemma: A Tale of Two Systems

My professional journey has afforded me a unique vantage point. In the NHS, resources are finite and strictly managed. The threshold for ordering a CTPA is high; one must rigorously justify the need for such a scan based on validated clinical scoring systems. There is a systemic gatekeeping process designed to prevent over-investigation.

Conversely, since moving to private practice in India, I have navigated a different landscape. Here, accessibility is a major strength—patients do not face long wait times. However, the threshold for investigation is noticeably lower. This is driven by several factors: a desire to provide immediate answers, the availability of patient funds or insurance, and, undeniably, a degree of defensive medicine. There is a pervasive fear of missing a diagnosis, leading to a "scan first, ask questions later" mentality.

While this low threshold offers a safety net, ensuring that even low-risk cases are not missed, it creates a new set of challenges. It shifts the focus from the patient’s clinical narrative to a binary image on a screen.

The Hidden Costs of Over-Investigation

My research emphasizes that skipping the step of proper clinical assessment does not just waste money—it carries tangible risks for the patient. We must consider the "costs" of a test in a holistic sense.

1. Resource Stewardship

Whether the funds come from a hospital budget or directly from a patient's pocket, healthcare resources should be utilized with precision. A CTPA is an expensive investigation. When we order scans for patients with a negligible clinical probability of PE, we divert resources (time, machinery, and personnel) away from those who may critically need them.

2. The Burden of Logistics and Stress

Undergoing a test involves significant organization. It requires the coordination of porters, radiographers, nurses, and reporting radiologists. For the patient, it is not merely a logistical hurdle; it is a source of profound anxiety. Being told one needs a scan to rule out a potentially life-threatening clot induces stress. If a thorough clinical examination and a simple blood test could rule out the condition with equal safety, subjecting a patient to the ordeal of a scan is, in my view, unkind.

3. Physical Risks and Patient Safety

Perhaps most importantly, we must remember that a CTPA is not a benign procedure. It carries inherent risks that are often glossed over in the rush for a diagnosis:

  • Radiation Exposure: While modern scanners are efficient, we are still exposing patients to ionizing radiation. In young patients, particularly women of childbearing age, this cumulative risk is significant.
  • Contrast Nephropathy: The dye used can impact kidney function, posing a risk to patients with pre-existing renal issues.
  • Allergic Reactions: Anaphylaxis to contrast media, while rare, is a life-threatening emergency.
  • Procedural Discomfort: We often forget the basics—cannula insertion causes pain, and the sensation of the dye entering the body can be distressing.

The Power of Clinical Rules

So, how do we find the balance? The answer lies in the rigorous application of clinical prediction rules, such as the Wells Score or the Geneva Score, combined with the PERC rule (Pulmonary Embolism Rule-out Criteria).

These tools allow us to stratify patients into risk categories:

  • Low Clinical Probability: In these patients, a negative D-dimer blood test is often sufficient to rule out PE without exposing the patient to radiation.
  • High Clinical Probability: These patients should proceed directly to imaging.

My research highlights that when these clinical rules are applied correctly, the diagnostic yield of CTPA increases significantly. We stop scanning healthy people and focus on those with true pathology.

The Art of the "Safety Net"

I acknowledge the fear of missing a diagnosis. In private practice, where the doctor-patient relationship is often direct and personal, the pressure to be 100% certain is immense. However, certainty should not come at the expense of clinical reasoning.

The "safety net" should not be a low threshold for radiation; it should be a high standard of clinical oversight. It involves taking a detailed history, performing a thorough examination, and understanding the patient's risk factors. It involves explaining to the patient why a test isn't needed just as clearly as explaining why one is needed.

People can indeed miss diagnoses, and human error is a reality. But the solution is not to abdicate our judgment to a machine. The solution is to sharpen our judgment.

Conclusion: Striking the Balance

The validity of clinical assessment in suspected pulmonary embolism is not just an academic concept; it is the bedrock of safe, ethical, and efficient medical practice.

As I continue my work in India, my goal is to bridge the gap between the rigorous protocols of the NHS and the accessible care of the private sector. We must strive for a practice where technology serves us, not leads us.

For my fellow clinicians, I urge you to trust your clinical acumen. Use the scoring systems. Look at the patient, not just the request form. For patients, I encourage you to ask questions. If a doctor suggests that a scan might not be necessary based on your clinical score, understand that this is often a sign of thoughtful, high-quality care that prioritizes your long-term safety.

Medicine is an art of balance. By respecting the validity of clinical assessment, we ensure that we are treating the person, not just the fear of a disease.

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About the Author

Dr. Sanjeev Agarwal

MBBS (Pat), MRCP (UK), CCST (UK), FRCP (London) - Founder & Director of Megastar Hospitals, Consultant Respiratory & General Physician, Honorary Clinical Lecturer at University of Liverpool with over 20 years of experience in respiratory medicine and healthcare innovation.

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